Description
Amitriptyline For Sale
Amitriptyline is the generic version of a medication sold under the brand name Elavil among others, which was discovered in the 1950s by scientists at the multinational pharmaceutical company Merck. It is on the World Health Organisation’s (WHO) list of essential medications and is widely used globally with millions of prescriptions each year. Amitriptyline tablets have a wide range of uses which we will go into more detail about a little later.
How Amitriptyline Works
Amitriptyline has a tricyclic chemical structure and strong anticholinergic properties. The exact mechanism of action is not fully understood, but it is thought to inhibit the re-uptake of noradrenalin and serotonin, meaning their concentration is increased and stays in the brain for longer before being removed or taken back up by the synapses. Synapses are microscopic gaps in between neurons which are brain cells, and the messages they send pass via the synapses. The signals which are sent are called action potentials and chemicals called neurotransmitters can regulate the rate of action potentials.
How Long Amitriptyline Lasts
Amitriptyline 10 mg is absorbed quickly via the gastrointestinal tract where is enters the cardiovascular system and then crosses the blood brain barrier into the brain where it exerts its effects. It has a bioavailability of between 30 and 60% due to first pass metabolism, which means that some of the medication is metabolised before it reaches the brain. After it has been absorbed it reaches peak plasma concentration after 2 to 12 hours, and this variation in time is thought to be due to genetic differences.
Amitriptyline Side Effects
Unfortunately, all medications have the potential to cause side effects, and this is why the lowest effective dose should always be used. Luckily, most people do not experience any and for those that do they are mild and resolve without the need for medical intervention. Nevertheless, before you buy amitriptyline it is important to be aware of any that may affect you. Some of the more common amitriptyline side effects include:
- Dry mouth
- Dizziness
- Headache
- Drowsiness
- Constipation
- Difficulty passing urine
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