– +1 805 3651170

– FREE SHIPPING FOR ORDERS OVER $250 –

  • English
    • French
    • German
    • Italian
Pain Relief Pills Shop – Weight loss Pills Online
0 Cart $0.00

No products in the cart.

  • Home
  • About Us
  • Blog
  • Cart
  • CBD Products
  • Checkout
  • Shop
  • Contact
  • Reviews
ASK YOUR PHARMACIST
logo main
  • Home
  • About Us
  • Blog
  • Cart
  • CBD Products
  • Checkout
  • Shop
  • Contact
  • Reviews
HomePain ReliefinsomniaDiazepam
diazepam 15 mg dose
(55 customer reviews)

Diazepam

$350.00

Quantity
Share
Add to Wishlist
Compare
Categories:insomnia, Pain Relief
  • Description
  • Reviews (55)

Description

Diazepam

diazepam 15 mg dose is available for oral administration as tablets containing 2 mg, 5 mg or 10 mg diazepam. In addition to the active ingredient diazepam, each tablet contains the following inactive ingredients: anhydrous lactose, magnesium stearate and microcrystalline cellulose.

Diazepam Tablets USP 5 mg also contain D&C Yellow No. 10.

Diazepam Tablets USP 10 mg also contain FD&C Blue No. 1.

CLINICAL PHARMACOLOGY

Diazepam is a benzodiazepine that exerts anxiolytic, sedative, muscle-relaxant, anticonvulsant and amnestic effects.

Pharmacokinetics

Absorption

After oral administration >90% of diazepam 15 mg dose is absorbed and the average time to achieve peak plasma concentrations is 1 – 1.5 hours with a range of 0.25 to 2.5 hours. Absorption is delayed and decreased when administered with a moderate fat meal. In the presence of food mean lag times are approximately 45 minutes as compared with 15 minutes when fasting. There is also an increase in the average time to achieve peak concentrations to about 2.5 hours in the presence of food as compared with 1.25 hours when fasting. This results in an average decrease in Cmax of 20% in addition to a 27% decrease in AUC (range 15% to 50%) when administered with food.

Distribution

Diazepam and its metabolites are highly bind to plasma proteins (diazepam 98%). Diazepam and its metabolites cross the blood-brain and placental barriers and are also in breast milk in concentrations approximately one tenth of those in maternal plasma (days 3 to 9 post-partum). In young healthy males, the volume of distribution at steady-state is 0.8 to 1.0 L/kg. The decline in the plasma concentration-time profile after oral administration is biphasic. The initial distribution phase has a half-life of approximately 1 hour, although it may range up to >3 hours.

Elimination

The initial distribution phase is followed by a prolonged terminal elimination phase (half-life up to 48 hours). The terminal elimination half-life of the active metabolite N-desmethyldiazepam is up to 100 hours. Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates. The clearance of diazepam is 20 to 30 mL/min in young adults.

Pharmacokinetics in Special Populations

Children

In children 3 – 8 years old the mean half-life of diazepam is 18 hours.

Newborns

In full term infants, elimination half-lives around 30 hours, with a longer average half-life of 54 hours in premature infants of 28 – 34 weeks gestational age and 8 – 81 days post-partum. In both premature and full term infants the active metabolite desmethyldiazepam shows evidence of continued accumulation compared to children. Longer half-lives in infants may be due to incomplete maturation of metabolic pathways.

Geriatric

Elimination half-life increases by approximately 1 hour for each year of age beginning with a half-life of 20 hours at 20 years of age. This appears to be due to an increase in volume of distribution with age and a decrease in clearance. Consequently, the elderly may have lower peak concentrations, and on multiple dosing higher trough concentrations. It will also take longer to reach steady-state. Reported changes in free drug may be due to significant decreases in plasma proteins due to causes other than simply aging.

Hepatic Insufficiency

In mild and moderate cirrhosis, average half-life increases. Reports for the average increase is from 2-fold to 5-fold, with individual half-lives over 500 hours reported. There is also an increase in volume of distribution, and average clearance decreases by almost half. Mean half-life is also an extension of the hepatic fibrosis to 90 hours (range 66 – 104 hours), with chronic active hepatitis to 60 hours (range 26 – 76 hours), and with acute viral hepatitis to 74 hours (range 49 – 129). In chronic active hepatitis, there is a decrease in clearance by almost half.

55 reviews for Diazepam

  1. Ike (verified owner) – 8 months ago

    Think everyone should know about this, it’s just beyond my expectations

  2. Franz (verified owner) – 8 months ago

    I rarely leave a comment, but this item is beyond worth it! Gotta let you guys know!

  3. Karine (verified owner) – 8 months ago

    It’s far better than those similar products, while the price is still acceptable.

  4. Cassandre (verified owner) – 8 months ago

    This is the best support for a product I had so far, they reply quickly and solve themselves the problems most of the time. Kudos guyz

  5. Kian (verified owner) – 8 months ago

    The first time I got the urges to leave a comment, but this is simply a top-notch thing you can find.

  6. Mabelle (verified owner) – 8 months ago

    I rarely leave a comment, but this item is beyond worth it! Gotta let you guys know!

  7. Lilla (verified owner) – 8 months ago

    Thank you guys for this amazing creation! Absolutely mind-blowing!

  8. Laney (verified owner) – 8 months ago

    An awesome product with great flexibility. The customer support is superb. I recommend this without any doubt.

  9. Bernie (verified owner) – 8 months ago

    This is the best support for a product I had so far, they reply quickly and solve themselves the problems most of the time. Kudos guyz

  10. Freida (verified owner) – 8 months ago

    The item and the design are very cool. Also the support is amazing, they always help you with any detail that you have.

  11. Coy (verified owner) – 8 months ago

    I got excellent support for this item. They were patient with me, and helped me solve my issue. I recommend this company 100%

  12. Erwin (verified owner) – 8 months ago

    I received a personalized and attentive treatment. Thanks to this deal, I was able to find a solution to my problem in a short time. 🙂

  13. Winifred (verified owner) – 8 months ago

    I’m caught 🙂 Find my love and will never buy in any other shop.

  14. Clarabelle (verified owner) – 8 months ago

    Wished I had found this sooner, it took me a lot of money and time until I found my dream product here!

  15. Fiona (verified owner) – 8 months ago

    I got excellent support for this item. They were patient with me, and helped me solve my issue. I recommend this company 100%

  16. Brady (verified owner) – 8 months ago

    I want to say thanks to the support team for helping with my continuously silly questions, you’re the best!

  17. Maymie (verified owner) – 8 months ago

    Great item! It provides too many things compared to its price charged.

  18. Gwendolyn (verified owner) – 8 months ago

    I’m caught 🙂 Find my love and will never buy in any other shop.

  19. Carley (verified owner) – 8 months ago

    The item and the design are very cool. Also the support is amazing, they always help you with any detail that you have.

  20. Collin (verified owner) – 8 months ago

    Been using it for a while, I usually don’t write a review but this time I am truly convinced to write.

  21. Trudie (verified owner) – 8 months ago

    Just love the design and the customer support is the nicest.

  22. Louie (verified owner) – 8 months ago

    Good response from the support.

  23. Alanis (verified owner) – 8 months ago

    An awesome product with great flexibility. The customer support is superb. I recommend this without any doubt.

  24. Candace (verified owner) – 8 months ago

    I’m caught 🙂 Find my love and will never buy in any other shop.

  25. Wava (verified owner) – 8 months ago

    I’m caught 🙂 Find my love and will never buy in any other shop.

  26. Marley (verified owner) – 8 months ago

    I like this item and also the customer service of them.

  27. Maurice (verified owner) – 8 months ago

    Been using it for a while, I usually don’t write a review but this time I am truly convinced to write.

  28. Houston (verified owner) – 8 months ago

    This is the coolest thing I’ve found on here! Will keep using your products in the future!

  29. Monique (verified owner) – 8 months ago

    Great item! It provides too many things compared to its price charged.

  30. Ezequiel (verified owner) – 8 months ago

    Wished I had found this sooner, it took me a lot of money and time until I found my dream product here!

  31. Ulises (verified owner) – 8 months ago

    An awesome product with great flexibility. The customer support is superb. I recommend this without any doubt.

  32. Gaston (verified owner) – 8 months ago

    I’m caught 🙂 Find my love and will never buy in any other shop.

  33. Mathias (verified owner) – 8 months ago

    I got excellent support for this item. They were patient with me, and helped me solve my issue. I recommend this company 100%

  34. Leonor (verified owner) – 8 months ago

    The first time I got the urges to leave a comment, but this is simply a top-notch thing you can find.

  35. Declan (verified owner) – 8 months ago

    Good response from the support.

  36. Josefa (verified owner) – 8 months ago

    Think everyone should know about this, it’s just beyond my expectations

  37. Orval (verified owner) – 8 months ago

    I got excellent support for this item. They were patient with me, and helped me solve my issue. I recommend this company 100%

  38. Alaina (verified owner) – 8 months ago

    Think everyone should know about this, it’s just beyond my expectations

  39. Camilla (verified owner) – 8 months ago

    Great item! It provides too many things compared to its price charged.

  40. Colin (verified owner) – 8 months ago

    I like this item and also the customer service of them.

  41. Murphy (verified owner) – 8 months ago

    I want to say thanks to the support team for helping with my continuously silly questions, you’re the best!

  42. Jerrold (verified owner) – 8 months ago

    This is the coolest thing I’ve found on here! Will keep using your products in the future!

  43. Bernardo (verified owner) – 8 months ago

    Thank you guys for this amazing creation! Absolutely mind-blowing!

  44. Walker (verified owner) – 8 months ago

    I rarely leave a comment, but this item is beyond worth it! Gotta let you guys know!

  45. Corine (verified owner) – 8 months ago

    This is the coolest thing I’ve found on here! Will keep using your products in the future!

  46. Laila (verified owner) – 8 months ago

    Just love the design and the customer support is the nicest.

  47. Maximilian (verified owner) – 8 months ago

    I want to say thanks to the support team for helping with my continuously silly questions, you’re the best!

  48. Salvador (verified owner) – 8 months ago

    This is the coolest thing I’ve found on here! Will keep using your products in the future!

  49. Anais (verified owner) – 8 months ago

    Thank you guys for this amazing creation! Absolutely mind-blowing!

  50. Archibald (verified owner) – 8 months ago

    Been using a lot of items, this one is obviously the best

  51. Alysha (verified owner) – 8 months ago

    Wished I had found this sooner, it took me a lot of money and time until I found my dream product here!

  52. Adelle (verified owner) – 8 months ago

    Been using a lot of items, this one is obviously the best

  53. Penelope (verified owner) – 8 months ago

    It’s far better than those similar products, while the price is still acceptable.

  54. Devyn (verified owner) – 8 months ago

    Good response from the support.

  55. Sid (verified owner) – 8 months ago

    Think everyone should know about this, it’s just beyond my expectations

Leave a Comment Cancel reply

Your email address will not be published. Required fields are marked *

12345

Related products

  • Oxycontin
    Select options
    Quick View
    Add to Wishlist
    Compare
    $300.00 – $400.00
    Oxycontin
    insomnia, Pain ReliefSelect options
    Quick View
    Add to Wishlist
  • Sertraline
    Add to cart
    Quick View
    Add to Wishlist
    Compare
    $350.00
    Sertraline
    Anxiety, Pain ReliefAdd to cart
    Quick View
    Add to Wishlist
  • Vyvanse
    Select options
    Quick View
    Add to Wishlist
    Compare
    $320.49
    Vyvanse
    ADHD, Pain ReliefSelect options
    Quick View
    Add to Wishlist

Blue Xanax
Alprazolam powder
Xanax green bars
White Xanax pills
Liquid Xanax

September 2023
M T W T F S S
 123
45678910
11121314151617
18192021222324
252627282930  
« Apr    

Where To Find Us

8712 California City Blvd
California City CA 93505, USA

Follow us

© 2021 Good Life Rx Pharmacy, All Rights Reserved

top
CLOSE
X
  • Login
  • Register
Add to cart